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ii) Ki67 (Cat# M724029, clone MIB1, Agilent, Santa Clara, CA, USA) to evaluate proliferation and iii) pan-cytokeratin (Cat# M082102, clone MNF116, Agilent, Santa Clara, CA, USA) as a guide for a training tumor stroma classifier

While the withdrawal effects of clomipramine hydrochloride capsules have not been systematically evaluated in controlled trials, they are well known with closely related tricyclic antidepressants, and it is recommended that the dosage be tapered gradually and the patient monitored carefully during discontinuation (see DRUG ABUSE AND DEPENDENCE)