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Ethics statement All experiments were approved by Oregon Health and Science University (OHSU) Institutional Animal Care and Use Committee (IACUC) (TR01_IP00000674) and conformed to the guidelines set by United States Animal Welfare Act and the National Institutes of Health

Vitamin B12 (Methylcobalamin or Cyanocobalamin) B12 is fundamental in many biological processes including DNA synthesis and fatty and amino acid metabolism

In Phase 3 TRIUMPH-1 (May 21, 2026), the 12 mg arm averaged 28.3% weight loss at 80 weeks, and a higher-BMI subgroup reached 30.3% at 104 weeks

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