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Oppositely, small animals (e.g., rats, mice, rabbits) have several obvious advantages, including easy breeding, low economic and time expenditure, and relatively high research throughput and data reproducibility, which encourages their widespread use in biomedical translation

Using flies and mice, it has been demonstrated that sleep deprivation results in the accumulation of ROS with consequent oxidative stress in the gut, rather than in the brain (Vaccaro et al

115 Antioxidants can also inhibit PARS activation, thus preventing organ damage resulting from inflammation

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