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In comparison to the control, MT3 knockdown considerably boosted the expression levels of NRf2 and its downstream antioxidant factors, HO-1 and CAT, in BMM and pOC, leading to less ROS production during osteoclast differentiation

Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression

Further studies revealed that ALAN may be responsible not only for the increase in tumor growth, but also for developing global DNA hypomethylation in the tumors of BALB/c short-day-acclimated mice inoculated with 4T1 breast cancer cells [101]

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