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Some research has shown the presence of reactive oxygen species and muscle level and their role in regulating muscle activity

[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Liu X, Yamada N, Osawa T

Despite these promising findings, future investigations should examine whether polyamine metabolism and pathways like the urea cycle influence GABA homeostasis 16 and contribute to tonic inhibition in PTSD

Women who are planning a pregnancy should be counseled regarding the relative risks and benefits of valproate use during pregnancy, and alternative therapeutic options should be considered for these patients [see Boxed Warning and Use in Specific Populations (8.1)]
