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Abbreviations AKI: Acute kidney injury ALL: Acute lymphocytic leukemia ALT: Alanine aminotransferase AM: Animal models AP: Alkaline phosphatase AP-1: Activator protein-1 ARE: Antioxidant response element AST: Aspartate aminotransferase BCCs: Basal cell carcinomas BUN: Blood urea nitrogen CAT: Catalase CIN: Chronic interstitial nephritis COX-1: Cyclooxygenase-1 COX-2: Cyclooxygenase-2 Cr: Creatinine CVD: Cardiovascular disease DIN: Drug-induced nephrotoxicity DNA: Deoxyribonucleic acid E