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Mitochondrial Ca 2+ overload also triggers apoptotic cell death by increasing ROS production and opening the mPTP [96]

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A comprehensive 2017 meta-analysis of 17 randomized controlled trials involving over 1,600 patients with chronic heart failure confirmed that targeted L-carnitine treatment significantly improves left ventricular ejection fraction and overall cardiac output

Details can be found at: 10.3389/fnagi.2026.1744201
