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The NanoinMicro strategy, which encapsulates nanoparticles within microparticles, enables efficient microparticle deposition in the lungs while facilitating the targeted delivery of nanoparticles, thereby harnessing their unique advantages as drug nanocarriers (Figure 1)

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The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary