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When these extracts showed biological activity, Khavinson's group systematically identified the shortest active peptide sequences responsible for the effects, creating synthetic analogs -- Epitalon from epithalamin, Vilon as a thymic dipeptide, Pinealon as a brain-targeted tripeptide

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Hemerkov P., Vali M

These findings demonstrate that solTNF inhibits remyelination and repair in a cuprizone demyelination model and suggest that local production of solTNF in the CNS might be one reason why remyelination fails in MS

Data Availability Statement Data sharing not applicable no new data generated, or the article describes entirely theoretical research.