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Most side effects from B12 shots resolve quickly, making them generally well-tolerated for routine supplementation

The Neelakantan 2018 paper showed strong oral absorption in cell uptake (Caco-2) assays, which is why most research community use is by mouth instead of by injection

As shown by connected scatterplot in Figure 4 (top-left), the Sucrosomial B12 formulation rapidly raised circulatory vitamin B12 levels above the deficiency threshold, exceeding 300 pg/mL (borderline level) from day 1

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