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1 Introduction The global prevalence of non-alcoholic fatty liver disease (NAFLD) has shown a consistent upward trend in recent decades, with current estimates indicating an overall prevalence of 30.05% ( In a pivotal 2023 consensus statement, international liver associations proposed redefining disease terminology, replacing NAFLD with metabolic dysfunction-associated steatotic liver disease (MASLD) and NASH with metabolic dysfunction-associated steatohepatitis (MASH) ( MASLD pathogenesis involves complex interactions among multiple pathological processes, including excessive fatty acid accumulation, dysregulated inflammatory responses, oxidative stress, and insulin resistance

Acknowledgments The authors would like to thank Aouatef Bellamine, for her help with study management and Suzanne Morris, at Concrete Medical Writing, LLC, for providing medical writing support (funded by Lonza)

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Lemonbottle's formulation and precision-guided injection technique offer patients a virtually painless experience with little to no swelling or bruising post-treatment