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4.3 Intestinal microbiota regulation While the pathogenesis of UC is still under investigation, the prevailing consensus among researchers suggests that environmental factors, in conjunction with the intestinal microbiota, act on genetically susceptible individuals, triggering immune-inflammatory responses that disrupt the intestinal barrier and lead to the development of UC (Mirkov et al., 2017)

Front Immunol (2018) 9:798

Environ Microbiol Rep 16:e70004

However, due to its synthetic nature it is also the least bioavailable and active (Hunt, Harrington and Robinson, 2014) Methylcobalamin: The first of our non-synthetic forms of B12 is methylcobalamin, a naturally occurring co-enzyme