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In addition to their detrimental effects on humans as endocrine disrupting chemicals (EDCs) and carcinogens [8,9,10], PAEs are also toxic to terrestrial and aquatic fauna comprising algae, molluscs, protozoan, crustaceans, invertebrates, and fishes [11]

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This receptor upregulation combines with BPC-157's activation of the Src-Caveolin-1-eNOS signaling cascade, which increases nitric oxide production by 1.35-fold and proves essential for the peptide's pro-migratory effects on endothelial cells