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Consuming more than 3 units/day (12-13 g alcohol/unit) increases the likelihood of cirrhosis in both men (OR 4.3) and women (OR 5.7), with a multiplicative interaction between alcohol intake and HBsAg positivity further elevating the risk (8)

Love DT, Barrett TJ, White MY, Cordwell SJ, Davies MJ, Hawkins CL (2016) Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages

Thus, glutamine metabolism serves as a metabolic rheostat for ferroptosis sensitivity by coordinately regulating iron homeostasis and oxidative stress