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Recently, reactivation of the JAK-STAT signaling pathway was demonstrated in a patient with refractory DRESS syndrome, triggered by the use of trimethoprim-sulfamethoxazole

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Lin et al., 2011) and that increases in histaminergic firing have been observed during periods of increased attention (Takahashi et al., 2006) and motivated behaviors (Torrealba et al., 2012)