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97 DS is an useful model for AD research since the majority of DS individuals show features of AD because APP is located on chromosome 21

Then, cells were resuspended in 300 l hybridization mixture (formamide 70%, blocking reagent 1, Tris-HCl, pH 7.4, 10 mM, locked nucleic acid probe 0.5 mM)

B12 also plays a crucial role in neurotransmitter production
