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Advantages and limitations of animal schizophrenia models
The results for NAC and carbocisteine led to a statement in the 2017 Global initiative for Chronic Obstructive Lung Disease (GOLD) guidelines listing these antioxidant/mucolytic drugs as an additional therapy to consider in the treatment of COPD
These small differences in efficacy of BLX2477 may be explained by the 3-log higher IC 50 of BLX2477 for free versus PE-esterified eicosatetraenoic acid (ETE) (Supplemental Figure 3)
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