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As acetyl-CoA stores are depleted, the synthesis of NAGA an important cofactor of CPS I from acetyl-CoA and glutamate by NAGA synthetase is decreased

So, TMAO can play an essential role in regulating inflammation and result in protective or causative effects, stimulating or attenuating the production of inflammatory cytokines that can attract more immune cells, forming a vicious circle that leads to foam cells formation and atherosclerosis development (81)

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Haemodialysis guidelines Intermittent HD can decrease blood ammonia concentrations by 75% within 34 h (ref
