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[74] Mechanisms such as Frster resonance energy transfer (FRET), photoinduced electron transfer (PeT), intramolecular charge transfer (ICT), aggregationcaused quenching (ACQ), and aggregationinduced emission (AIE) are employed in activatable fluorescent probe to interfere with these light absorption or fluorescence decay pathways, keeping the fluorophore in an inactive state.[ 75 , 76 , 77 , 78 , 79 , 80 ] The quenching mechanisms underlying activatable fluorescent probe can and have been applied successfully to also interfere with photosensitizer ISC from S 1 to T 1 , effectively silencing the photosensitizer fluorescence and ROS generation until it encounters a diseaserelevant stimulus.[ 81 , 82 ] Examples of aPS quenching mechanisms are provided in Figure 2 and will be overviewed in this section