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Gupta S, Tyagi S, Almeida DV, Maiga MC, Ammerman NC, Bishai WR

minutes from lights off to the first epoch of 20 consecutive (30-second) epochs of non-wakefulness proportion of time spent asleep per Time in Bed (TIB), calculated as Total Sleep Time (TST)/interval from lights off until lights on minutes of wake from the onset of persistent sleep until lights on minutes of wake during the interval from 240 minutes after lights off until lights on estimated minutes from the time that the subject attempted to sleep until sleep onset pproportion of subjective total sleep time per subjective time spent in bed sum of estimated minutes of wake during the night after initial sleep onset until the time the subject stopped trying to sleep for the night, operationalized as the time the subject got out of bed for the day DAYVIGO reduced time to sleep onset, as assessed by the primary endpoint (mean* change from baseline in LPS vs placebo at Month 1)

G., Costa, J., & Gulasekaram, B

Although our in vivo data robustly demonstrate multi-system recovery, the intricate cellular and molecular crosstalk underlying these effects invites further elucidation through reductionist in vitro models