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doi: 10.1038/nature11986 152 LaGoryELGiacciaAJ
However, several challenges exist in the application of such combination treatment strategies
Notably, canonical GPX4 inhibitors, such as RSL3 and ML162, also inhibit thioredoxin reductase 1 (TXNRD1) 121,122
[2] Symptoms of deficiency include fatigue, weakness, pale skin, shortness of breath, and neurological disturbances such as paraesthesia, ataxia, and cognitive changes
