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In contrast to aforementioned approaches, this method is not based on phosphoramidite- or active-ester- chemistry, it opens a new third route, that of oligonucleotide direct functionalisation

Third, these compounds often exhibit poor stability, degrading quickly under physiological conditions, which reduces their efficacy

2024A1515030079, J.H.), Key Areas Research and Development Program of Guangzhou (202007020006, X.S.), China Postdoctoral Science Foundation (2021M703763, B.L

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