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M1-like macrophages are responsible for secreting pro-inflammatory cytokines and lipid mediators and are involved in tissue degradation and T lymphocyte activation as part of an inflammatory immune response (Reference Gordon and Taylor19)

Hypertension 74(3):477492 Hamara K, Bielecka-Kowalska A, Przybylowska-Sygut K, Sygut A, Dziki A, Szemraj J (2013) Alterations in expression profile of iron-related genes in colorectal cancer

doi: 10.1080/09291016.2019.1621064 39 AlhussienMManjariPSheikhAASemanSMReddiSMohantyAKet al

As highlighted in a recent systematic review 37 , there remains a need for high-quality observational data on biosimilar safety