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This induction in BALB/c was entirely dependent on IL-4RA, IgE- and FCER1A-expressing cells and could be partially prevented by pretreating mice with zileuton (ALOX5 inhibitor), montelukast (CysLTR1 inhibitor) or HAMI3379 (CysLTR2 inhibitor) before each challenge (Fig
Immune cells, such as macrophages and neutrophils, can also generate ROS due to their oxygen-dependent mechanisms to fight against invading microorganisms based on NOX2 isoform ( ROS are produced in mitochondria during aerobic metabolism (Rodriguez and Redman, 2005)
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The inflammatoryoxidative amplification loop may further destabilize the decidual microenvironment (62)
