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Used when sustained cognitive performance across a working day is the endpoint, and when the researcher wants to maintain consistent neurotrophin upregulation

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The intracellular domain has three portions: a juxtamembrane sequence that downregulates kinase activity which is followed by phosphorylation of Ser975 which is a catalytic region that promotes kinase activity leading to transphosphorylation of Tyr1234 and Tyr1235

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