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TUNEL Terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate nick-end labeling the molecular pathologic processes believed to occur in smallpox take a toll on GSH concentrations: (a) induction of iNOS with increased NO production, (b) the generation of superoxide, (c) formation of peroxynitrite, (d) GSH-consuming chain reactions of ROS and RNS, (e) TNFa related oxidative stress, the induction of Cox-2 with increased oxidation of arachidonic acid, (g) oxidative bursts from macrophages engaged in phagocytosis at sites of infection and inflammation, and related cascades

[DOI] [PubMed] [Google Scholar] 48.Reddy N.M., Kleeberger S.R., Yamamoto M., Kensler T.W., Scollick C., Biswal S., Reddy S.P

1 , e004093 (2012)