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In turn, the impairment in -oxidation can shift the metabolism of VPA toward predominantly peroxisomal -oxidation, resulting in excessive production and accumulation of -oxidation products, including 4-en-VPA a metabolite that is incriminated in VPA-induced hepatotoxicity

Exposure and Potential Confounders Overnight fasting (8 h) venous blood samples were collected using vacuum tubes containing EDTA

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Garduo-Garcia J de J, Alvirde-Garcia U, Lpez-Carrasco G, Padilla Mendoza ME, Mehta R, Arellano-Campos O, et al