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A primary mechanism underlying this toxicity is oxidative stress, evidenced by increased lipid peroxidation (malondialdehyde MDA) and depletion of antioxidant defenses (superoxide dismutase SOD) within reproductive tissues, leading to inflammation and cellular damage 7

Hattori H, Mori T, Shibata T, Kita M, Mitsunaga T. 6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise. Mol Nutr Food Res. 2021 Apr 1:e2100185. doi: 10.1002/mnfr.202100185. Epub ahead of print. PMID: 33793045

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Schwarz, M., Russell, D.W., Dietschy, J.M