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In studies examining muscle regeneration following injury, NNMT inhibition promoted stem cell activation and improved healing outcomes

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High NNMT expression is closely associated with glucose dysregulation: excessive NNMT activation disrupts nicotinamide metabolism, lowers NAD+ levels, impairs insulin signaling, reduces cellular glucose uptake and utilization, and promotes hyperglycemia and insulin resistance

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doi: 10.1152/ajpendo.2006.263.6.E1063

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This represents an average additional fat loss of about 1.8 kg (4 pounds) over 12 weeks attributable to the peptide

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