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The zebrafish modelcharacterized by high-throughput screening capacity, optical transparency, genetic tractability, and cost efficiencyis rapidly transitioning from a basic research tool to a pivotal platform bridging mechanistic investigation and clinical translation (Figure 5A) (Patton et al., 2021

The activity reverts to the original level within 23 days if the agent is withdrawn

Together, changes in ceramide metabolism appears to modulate mitochondria membrane structure in neurodegenerative diseases

The synthetic protein specifically inhibits ubiquitin-specific protease 2 (USP2a), resulting in decreased levels of MDM2, a negative regulator of p53 tumor suppressor