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A separate ligament study (Cerovecki et al., 2010, Journal of Orthopaedic Research ) reported improved medial collateral ligament healing in rats over 90 days post-transection, with effective dosing observed across intraperitoneal, oral, and topical routes

They can cause significant muscle loss along with fat loss, which some research suggests may be as high as 30-40% of total weight lost

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Such uncoupling was also evidenced in vivo after chronic opioid agonist exposure
