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1995), and they were proposed to regulate key metabolic pathways (Shaikhali 2008)

Regarding delivery, most ferroptosis inducers are small-molecule compounds with diverse chemical properties and stability profiles, complicating their efficient delivery to target cells or tissues
Recent findings from preclinical and clinical studies on IS have confirmed a bidirectional regulatory relationship between IS and gut microbiota dysbiosis, establishing the MGBA as a novel therapeutic target for ischemic stroke

This results in the extrusion of intracellular contents and subsequent necrosis (Yoon et al., 2014
