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(6) People with cirrhosis have a 1 to 4 percent annual risk of developing liver cancer and a 3 to 6 percent risk of hepatic decompensation (the development of serious, life-threatening liver-related problems)
Another mechanism may involve activation of sirtuins, especially sirtuin1 (SIRT1) and its transcriptional co-factor peroxisome proliferator-activated receptor- coactivator 1 alpha (PGC-1), although few data of human studies are available 26
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