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NICE guidance on type 2 diabetes management (NG28) emphasises individualised treatment approaches and shared decision-making between patients and healthcare providers
Adds to the promotion of testosterone's overall effectiveness

Methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

As fumarate is further metabolized into malate and then oxaloacetate, it facilitates the production of NADH and FADH2crucial electron carriers that feed directly into the electron transport chain to maximize ATP synthesis