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Importantly, anti-PCSK9 therapy will decrease circulating LDL cholesterol while increasing the exposure of PCSK9- and LDLR-expressing tissues to LDL cholesterol, perhaps providing a partial explanation for the contradictory anti- and pro- cancer effects of PCSK9 inhibition seen in different tumor models

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Bone 80, 7988

doi: 10.1111/j.1476-5381.2011.01604.x 84 KayaM