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Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]
10.1007/978-1-4615-9400-0_4 82 LuzzattoL.NannelliC.NotaroR

Pregnenolone is a precursor of other steroid hormones

How does this mutation transfer globally
