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Introduction Colorectal cancer (CRC) is the third most frequent cancer, with nearly 1.89 million new cases diagnosed in 2020, and the second most common cause of cancer-related death ( Within the same patient or even the same tumor, multiple mechanisms of drug resistance can coexist, and this is generally thought to be due to rare, stochastic genetic alterations ( in vitro from commercial cell lines or in vivo from patient-derived xenografts, and they present across various kinds of tumors ( Drug-tolerant persister cells may eventually acquire irreversible resistance-conferring genetic mutations and bona fide drug-resistance mechanisms to avoid eradication by prolonged lethal exposures ( 2+ ), can create ROS by participating in the Fenton reaction, thereby triggering ferroptosis ( In this study, we followed a previously established procedure ( in vitro

Expression and function of heme oxygenase-1 in human gastric cancer

The images were acquired in the Leica SP8 microscope in confocal mode with HC PL APO 63x/1.40 OIL CS2 oil immersion objective and post-processed with the Lightning super resolution module

2-Deoxy-D-glucose (2-DG) was purchased from MedChemExpress (HY-13966, USA)