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doi: 10.1167/iovs.07-1355 199 SappingtonR
Inadequate absorption or utilisation of Vitamin B12 because of age, gastric abnormalities such as Coeliac disease, inflammation of the stomach or intestines, after stomach and bowel surgery, and inflammatory bowel diseases (Crohns disease)
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The normalized expression data was further simplified to a trinary matrix with values of 1 (for overexpressed genes), 0 (no change), and -1 (underexpressed genes), using the previously obtained fold change values
