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13 found that during inflammation, the SREBP cleavage activating protein (SCAP)-Sterol regulatory element binding protein 2 (SCAP-SREBP2) complex, an important cholesterol receptor, promotes the activation of the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome, thereby linking cholesterol synthesis to inflammatory signaling, which together promote macrophage activation and inflammation

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