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1,2,3,4 As a bioactive lipid mediator, LPA signals primarily through six G protein-coupled receptors (GPCRs) termed as LPA receptors, LPAR16, which modulate key cellular functions such as proliferation, survival, motility, cytoskeletal remodeling, and immune regulation

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Moreover, TRAF6 signalling initiates the MAPK pathway, which in turn leads to the stimulation of activator protein 1 (AP-1) and cAMP-responsive element-binding proteins, leading to the production of proinflammatory cytokines and chemokines