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Cell 174(4):9991014.e1022

Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death

AMPK induces the expression of proteins involved in OXPHOS, such as peroxisome proliferator-activated receptor (PPAR)- coactivator (PGC) 1, a transcriptional coactivator that promotes mitochondrial biogenesis 63 , and the activities of mitochondrial enzymes, including succinate dehydrogenase (SDH) 64

It suggests that the same powerful, systemic healing mechanisms that make it a subject of interest for orthopedic injuries could have profound implications for skin health, wound closure, and tissue regeneration