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methionine synthase, CBS

[DOI] [PubMed] [Google Scholar] 254.Palumbo S, Toscano CD, Parente L, Weigert R, Bosetti F

10.1126/science.aan4183 Science 5 ChanW.AlmasiehM.CatrinescuM.-M.LevinL

Pharmacodynamics: The observed pharmacodynamic effects in animal models often outlast measurable systemic exposure, suggesting mechanisms that include local tissue modulation, induction of growthfactor expression, and initiation of reparative cascades rather than sustained receptor occupancy requiring prolonged systemic presence
