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These fibres have both extrinsic (eg, cervical, sphenopalatine and trigeminal ganglia) and intrinsic (eg, locus coeruleus, fastigial nucleus, and dorsal raphe nucleus) origins (Willie et al, 2014)

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Self-treatment can lead to addiction to NSAIDs and serious consequences related to changes in the digestive system, kidneys, liver, or respiratory system in people with asthma

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