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Several mechanisms have been proposed to explain chronic hyperglycemia-induced nerve damage, such as intracellular accumulation of sorbitol, glycation reactions, and oxidative and nitrosative stress (reviewed in 69)
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The increase in glutamate and aspartate in breast cancer is mediated by EAAT2 (42)
Regarding weight management , NHS guidance is unequivocal: B12 supplementation is not recommended as a weight loss intervention
