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doi: 10.1016/j.jgar.2018.11.003 24 AzimiL.ArminS.Samadi KafilH.AbdollahiN.GhazviniK.HasanzadehS.et al

Most people wont notice, and the loss is part of a hairs natural life cycle, so it usually isnt a cause for concern

Blood 98, 2001

Class II variants also have severe enzyme deficiency (less than 10% of normal), but there is usually only intermittent hemolysis
