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Topics discussed within clusters range from emerging scientific and ethical issues to challenges in product development to issues with the review of marketing authorization applications (see Figure 5-8)

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There are two main reasons for a blockage at this angle: either the angle remains open and the fluid has complete access to the trabecular meshwork but for some reason its outflow is impeded (open angle glaucoma), or there is a physical barrier in the angle, sometimes caused by deformity in the iris, that causes reduced flow (closed angle glaucoma)