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In CRS mice, THC administration reversed anxiety- and depressive-like behaviors (open field, tail suspension, and forced swim tests), normalized prefrontal cortex (HSP90, KRT6A, P4HB, C1QA, APOM, CDH13) and hippocampal (HSP90, P4HB, CDH13) protein expression in mice, and restored serum levels of P4HB, C1QA, and CDH13 in both humans and mice, while additionally modulating LTF, TNF-, IL-1, cAMP, and DA in mice serum

however, in patients with non-pulsatile bilateral tinnitus, with or without symmetric hearing loss, and an otherwise normal history and physical exam, imaging is not necessary