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Description
The reactive chemical 4-HNE is known to bind and form adducts to macromolecules including DNA [80], and cell culture studies demonstrate that Nrf2 and glutathione are needed to protect cells from 4-HNE and lipid peroxidation toxicity [81]

Biologically, these three peptides promote tissue repair through distinct but complementary mechanisms
Dysregulated trafficking (e.g., reduced ACSL4 transport to the ER) modulates PUFA esterification and peroxidation risk (109)

Given this strong correlation, we used the DdCBE expression level as a proxy for heteroplasmy