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Lisdexamfetamine and D-amphetamine also produced similar peak increases in mean arterial blood pressure, heart rate, body temperature, pupil size, and adverse effects

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As aquaporin-4 is mainly localized in the astrocyte endfeet, these are the primarily affected cells in this disease
Such damage disrupts the ability of neurons to transmit nerve impulses, resulting in a widespread of disease manifestation and numerous symptoms including physical, sensorial, cognitive, and sometimes psychiatric problems (Miller et al., 2005)