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Plasma lipids can be highly variable in children and a precise diagnosis of a lipid disorder that requires drug therapy may necessitate at least a second sample in the fasting state

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Among these compounds, the two penta-hydroxyflavonoids (quercetin and morin), showed the best performance, suggesting that the presence of hydroxyl groups at these specific positions are key factors significantly increasing the efficacy of hydroxyflavonoids as MALDI matrices (Figure )

225 Administration of the PRMT4 inhibitor TP-064 in a mouse model of atherosclerotic cardiovascular disease can induce a decrease in monocyte tumor necrosis factor- (TNF-) secretion, downregulate the gene expression of the glycogen metabolism-related protein G6pc in the liver, and reduce plasma triglyceride levels, exerting regulatory effects from inflammatory and metabolic pathways
